A cyst is simply a round fluid-filled mass (much like a water balloon). They can be found in almost every part of the body. The kidney is one of the most common sites for cysts. These are infact so common that about 50% of adults who have a kidney ultrasound will be found to have at least one kidney (or renal) cyst. Nearly all cysts are perfectly benign, of absolutely no threat, and need not be treated or followed. However, rarely a kidney cancer can appear "cystic", although it will have characteristics on imaging that make it obvious it is not a "simple cyst". On the other hand, some perfectly benign cysts can have atypical features. Your urologist will discuss with you the chance of whether your particular cyst is benign or not and discuss with you management options.
There are several other "cystic diseases" of the kidneys, including so-called "polycystic kidney disease" (PCKD). this is usually an inheritable condition of progressive production of many cysts in the kidneys through adult life. The kidneys can literally become replaced with innumerable cysts that lead eventually to kidney failure. There is usually a family history of PCKD, and/or the presence of MANY renal cysts at dianosis, not just 2 or 3 in a kidney.
Cystic tumors may be benign (such as "multilocular cystic nephroma") or malignant. Your urologist will discuss the details of this in you case if he suspects either of these relatively rare conditions.
What causes benign simple cysts to occur is still unknown. There is nothing that can be done to prevent them, nor need there be as they are extremely common and non-threatening.
An ultrasound usually first demonstrates the presence of one or more renal cysts. If the radiologist is satisfied that the cyst(s) satisfies the criteria of a simple cyst, nothing more is necessary. If there is any doubt, then depending on certain factors it may be recommended that a CT scan be done to decide if the cyst in question is indeed benign or not. Sometimes we will simply follow with another ultrasound in a few months to reassess.
Ultrasound and CT are complementary. Ultrasound is very good at establishing the presence of fluid - which is critical in differentiating simple benign cysts from small solid renal masses (some of which are cancerous). CT is not as good for small lesions, but good in defining solid tumors as well as extent of tumor.
Simple cysts require no treatment and usually no followup is necessary. When appropriate imaging is performed and the presence of a simple cyst is confirmed, cancer is not a concern. No matter what their size, simple cysts almost never cause any problems - if you have a simple cyst (especially if it is less than 10 cm) and any kind of symptoms, another cause should be sought. Rarely, problems can arise and include:
PCKD is best followed by a nephrologist for prevention and delay of renal failure as well as genetic counselling. A cystic tumor where cancer cannot be ruled out may require surgical removal.
In some cases, cysts can be serious. A commonly used classification of cysts is the Bosniak classification system. It is quite good at the extremes where either a benign lesion or malignancy can be specified with good certainty, but in the middle ground, follow-up is sometimes advisable where the diagnosis is uncertain.
Benign simple cyst
Thin wall (no internal echoes, sharpley defined walls, round or ovoid). No enhancement on CT
Benign minimally complicated cyst
The vast majority of these are non-cancerous. Out of the tens of thousands of Bosniak II renal cysts, there have only been a few case reports of malignancy developing in these cysts. They always have a thin wall. May have any of the following:
Sometimes repeat imaging
Some of these can be cancerous. Some of the components may enhance when contrast is given during CT. May have any of the following
Sometimes repeat imaging
Usually remove cyst or kidney.
Malignant (cancerous cyst)
May have any of the following:
|Usually removal of the cyst or kidney|
Angiomyolipoma (AML) is a non-cancerous (benign) tumor of the kidney. They are comprised of 3 components
Definitive diagnosis can often be made with CT scan as fat has a very specific appearance on CT and other types of fat containing tumors are exceedingly rare. There are instances where the amount of fat is too small to detect with CT scan and a definitive diagnosis cannot be made.
The primary risk associated with AML is bleeding. The blood vessels are thin walled and can rarely spontaneously rupture. The risk of bleeding increases with the size of the tumor but is very rare with tumors less than 4-5 cm in size. Tumors that are larger can be considered for angioembolization - a radiologic procedure to cut off the blood supply to the tumor.
AML has been associated with tuberous sclerosis. In most cases, tuberouse sclerosus associated AML are multiple and occur in both kidneys. Tuberous sclerosus requires multiple clinical features to make a diagnosis. More information can be found with these links: TS-associated skin conditions, updated diagnostic criteria.
Canadian Urological Association Extenstive library of downloadable pamphlets on a wide range of urological conditions
Medline Plus Produced by the US National Institutes of Health with information on virtually every health topic and extensive list of links
UrologyHealth.org The patient information site of the American Urological Association.